Novel Psychoactive Substances (NPS):
“A new narcotic or psychotropic drug that is not controlled by the United Nations Drug Conventions but which may pose a public heath threat.”
The Center for Forensic Science Research and Education (CFSRE) at the Fredric Rieders Family Foundation, in collaboration with law enforcement, public health, and public safety agencies, is working towards the rapid identification of emerging drugs associated with intoxications and adverse events, including mass hospitalizations and death, and the rapid dissemination of information to stakeholders and effected communities. For questions or more information about this collaboration, please contact NPS Discovery at NPSDiscovery@frfoundation.org.
NEW NPS DISCOVERIES
The CFSRE, in collaboration with NMS Labs, the Organized Crime Drug Enforcement Task Force (OCDETF) in the Department of Justice, Temple University, and the National Institute of Justice has documented the first known reports of novel psychoactive substances (NPS) in the United States through analysis of both seized materials (SM) and biological fluids (BF). These reports were generated using comprehensive analytical techniques (e.g. GC-MS, LC-QTOF, NMR, and LC-QTOF) for identification of NPS listed below. These reports are intended to assist the forensic science community in the rapid identification of NPS in casework.
To download full details for a specific analyte featured in the table below, simply click on its name. A sortable excel spreadsheet featuring ALL analytes listed below is available by clicking here: Downloadable NPS Spreadsheet (Updated 4/24/19)
For questions, more information about this collaboration, or if you would like to be included on the distribution list for the reports of these emerging NPS, please email please contact NPSDiscovery@frfoundation.org.
|Analyte (click for full profile)||Sample Type||Date of Report||Chemical Formula||Molecular Weight||Molecular Ion [M+]||Exact Mass [M+H]+|
|Deschloro-N-ethyl Ketamine (O-PCE)||BF||6/1/2018||C14H19NO||217.3||217||218.1539|
|5F-MDMB-PICA||BF & SM||7/31/2018||C21H29FN2O3||376.5||376||377.2235|
NPS TREND REPORTS
The Center for Forensic Science Research and Education (CFSRE) at the Fredric Rieders Family Foundation has received funding from the National Institute of Justice (NIJ) of the Department of Justice (DOJ) to develop trend reports associated with novel psychoactive substances (NPS) in the United States. These trend reports are intended to provide near real-time information regarding NPS prevalence and turnover. Testing was performed using biological fluids, sample extracts, and/or datafiles. For questions or more information about this collaboration, please contact NPS Discovery (email@example.com).
2019 Trend Reports:
2018 Trend Reports:
VII NPS International Conference: Washington D.C. Fall 2020
We are pleased to announce the VII International Conference on Novel Psychoactive Substances to be held in Washington DC, Fall 2019!
ABOUT THE CONFERENCE : The 2020 conference is jointly organized by the CFSRE, the University of Hertfordshire, the United Nations Office on Drugs and Crime (UNODC), the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), and the World Anti-Doping Agency (WADA).
NPS Workshops: Clinical Impacts and Management, Interventions, Risks and Harms, Nomenclature and Analysis & More to be Announced
NPS Topics: Use, Settings Experiences and Trends, Detection Identification and Characterization, Pharmacology/Toxicology, Prevention, Harm Reduction, Treatment and Clinical Management, Performance and Image Enhancing Drugs, Monitoring, Policy and Legislation & More to be Announced
Date & venue announcement coming soon. Click here to download the event flyer. Request updates by emailing: Contact@frfoundation.org and check back here for updates
New Synthetic Cannabinoid: 4F-MDMB-BINACA
January, 31, 2019
The objective of this public announcement is to notify public health and public safety, law enforcement, clinicians, medical examiners and coroner, laboratory personnel, and all other related communities about new information surrounding the emergent synthetic cannabinoid 4F-MDMB-BINACA. CLICK HERE TO DOWNLOAD OFFICIAL PUBLIC ANNOUNCEMENT AND FULL DETAILS
Santa Muerte Mass Overdose Outbreak
TOOLS FOR IDENTIFYING NPS
The identification and characterization of NPS can often be complex and time consuming, but there are numerous resources available for laboratories looking to discover an unknown substance in casework. The below resources allow laboratory analysts to search for data corresponding to NPS identified and reported by other agencies or laboratories. Some resources are searchable by NPS name or formula, while others allow for direct spectra comparisons. Although these sources are extensive, newly emerging NPS may not be available. For questions about these resources or assistance with your identifications, please contact NPSDiscovery@frfoundation.org.
- Cayman Chemical
- Data Search System for New Psychoactive Substances
- Designer Drugs Online Mass Spectral Database
- European Project Response to Challenges in Forensic Drug Analysis
- Mass Bank – High Resolution Mass Spectral Database
- MZ Cloud – Advanced Mass Spectral Database
- New Synthetic Drugs Database
- NPS Data Hub
- Southern Association of Forensic Scientists
- Spectral Database for Organic Compounds (SDBS)
MJ Menendez at National Opioid Summit
On October 25th 2018 our good friend, MJ Menendez spoke at the National Opioid Summit hosted by the Justice Department. During her presentation, she gave us a mention for the work we are doing in the identification & discovery of NPS. To view her presentation on CSPAN (16:50), click HERE.
Thank you to all who attended the USA NPS Symposium
We would like to extend our thanks and appreciation to our distinguished guest-lecturers, presenters and attendees who contributed to the 2018 Symposium on Novel Psychoactive Substances in November 2018 – the first of its kind in the United States of America. Also a special thank you to our wonderful hosts at the Science History Institute in Philadelphia, PA.
This two-day symposium was designated to highlight the current state of the NPS crisis in the United States by examining topics ranging from the manufacture and distribution, efforts at interdiction and disruption, understanding motivations for NPS use, and public health impacts in both emergency medicine and morgues.
For this symposium, an outstanding series of multidisciplinary panelists were assembled. The symposium design and panel discussions were structured to create an international forum that will foster an open dialogue regarding all aspects of the NPS phenomenon. The goals of the symposium included identification of the gaps regarding the communication, prioritization and cooperation on novel substance identification and fostering ideas for opportunities to improve dissemination strategies.
For those who were unable to attend, to view the presentations which were delivered by our NPS Symposium lecturers, simply click the name of the presentation:
November 13, 2018
Session I: Plenary Panel on the International State of NPS Identification, Interdiction and Control; Moderator Barry Logan
- Global Perspective – The UNODC Early Warning Advisory Toxicology Portal (Conor Crean PhD, UNODC Laboratory and Scientific Section, Vienna, Austria)
- Best Practices in Addressing NPS – What’s Working Worldwide? (Roumen Sedefov MD, EMCDDA, Lisbon, Portugal)
- The Need for Interdisciplinary Solutions to the NPS Problem (Ornella Corazza PhD, University of Hertfordshire, United Kingdom)
- Characteristics of Working Interdisciplinary Models for Rapid Notification (Barry Logan PhD, Center for Forensic Science Research & Education; NMS Labs, Willow Grove PA, USA)
Session II: Origins and Impact of the NPS Drug Problem; Moderator Tom Gilson
- Addiction and the Specific Appeal of NPS (Robert Dupont MD, Institute for Behavior and Health, Rockville MD, USA)
- Current NPS Market Worldwide and Historical Perspectives (Rachel Christie PhD, EMCDDA, Lisbon, Portugal)
- The Origins and Evolution of NPS from 2008-2018 (Sherri Kacinko PhD, NMS Labs, Willow Grove PA, USA)
Session III: Trends, Data and Resources for Tracking the NPS Market; Moderator Rob Middleberg
- Systems in US Public Health for Measuring Drug Related Deaths with a Focus on Opioids (Grant Baldwin PhD, MPH, Centers for Disease Control and Prevention, Atlanta GA, USA)
- Drug Adulteration in the NPS Market: A Case Study of Brodifacoum in Synthetic Cannabinoids in Summer 2018 (Tegan Boehmer PhD, MPH, Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, Atlanta GA, USA)
- Analysis of Drug Trend Data: Integration of Seized Drug Data and Public Health Data (Jane Maxwell PhD, The University of Texas at Austin, Austin TX, USA)
Session IV: Tools for Interdiction and Prosecution in Tackling NPS Supply and its Consequences; Moderator Jerry Daley
- Federal Response in Disrupting the Distribution of NPS in the United States (Raymond Donovan, Drug Enforcement Administration, Washington DC, USA)
- Challenges of Providing Support to Enforcement Efforts in the Federal Model (Patricia Hawes, U.S. Customs and Boarder Protection, Washington DC, USA)
- Legal Theories for Prosecution of NPS related Crimes including Drug Trafficking and Drug Delivery Homicide (Menendez JD, Organized Crime Drug Enforcement Task Force, U.S. Department of Justice, Washington DC, USA)
An International Perspective on Best Practices in Addressing the Challenges of NPS
- Diffusion of NPS Among Athletes: A Laboratory Perspective (Francesco Botrè, Sapienza University of Rome, Rome, Italy)
- NPS Prohibited in Sport: Status and Challenges (Irene Mazzoni PhD, World Anti-Doping Agency, Montreal, Canada)
- Overview of NPS in Singapore (Angeline Tang, Health Sciences Authority, Singapore)
- Novel Psychoactive Substances in a Large Ohio Jurisdiction, 2016 to Present (Thomas Gilson MD, Cuyahoga County Medical Examiner’s Office, Cleveland OH, USA
- Utilizing ODMAP For Data Driven Decision Making Through Collaborations (Aliese Alter, Washington/Baltimore HIDTA, Washington DC, USA
November 14, 2018
Session V: Advancing our Understanding of NPS Activity and Toxicity; Moderator Marilyn Huestis
- Laboratory Based Assessments of NPS Activity, Function and Potency (Michael Baumann PhD, National Institute on Drug Abuse, Baltimore, MD, USA
- Strategies for Forecasting Evolution of New Drugs and Drug Classes (István Ujváry PhD, University of Budapest, Hungary)
Session VI: Public Health Challenges and Impacts of NPS; Moderator Kendra Viner
- The Role of Public Health in Combatting Designer Drug Use (Denise Paone PhD, Bureau of Alcohol and Drug Use Prevention, Care and Treatment NYCDOHMH, Long Island City NY, USA)
- Challenges of Diagnosing and Treating NPS Intoxications in the Emergency Room (Mark Neavyn MD, University of Massachusetts Medical School, Boston MA, USA)
- Medicolegal Death Investigations involving NPS – Challenges in Certification and Reporting (Roger Mitchell MD, Office of the Chief Medical Examiner, Washington DC, USA)
- A European Perspective on Systems to Monitor and Detect Acute NPS Toxicity (Paul Dargan MD, Guys and St. Thomas, London)
Session VII: Laboratory Support for Timely Identification of Emerging NPS; Moderator Sherri Kacinko
- SWGDRUG and Characterization of New Substances, Library Building and Online Resources for Drug Identification (Scott Oulton, Drug Enforcement Administration, Washington DC, USA)
- Toxicological Characterization of NPS Screening – Rapidly Expanding Scope of Routine Analysis (Donna Papsun MS, NMS Labs, Willow Grove PA, USA)
- Analyte Targeting for NPS Identification in Seized Drugs and Toxicology (Alex Krotulski MS, Center for Forensic Science Research and Education, Willow Grove PA, USA)
Session VIII: Timely Use of NPS Data to Support Public Health Responsiveness and Preparedness; Moderator Robert Bassett
- Public Health Emergencies with NPS and Tracking and Investigating Outbreaks (Roy Gerona PhD, University of California San Francisco, CA USA)
- CDC’s Enhanced State Opioid Overdose Surveillance Program: Tracking NPS Overdoses (Julie O’Donnell PhD, Centers for Disease Control and Prevention, Atlanta GA, USA)
- The American College of Medical Toxicology ToxIC Registry: Applications in NPS Surveillance (Alex Manini MD, Icahn School of Medicine at Mount Sinai in New York City, New York, NY, USA)
Once again, we sincerely thank everyone who participated in this processes and we are eager to continue working together in the spirit of collaborative progress.