Applied Pharmacokinetics Course (Online)
Jul. 6, 2020 - Jul. 8, 2020
Tuition Cost: $450 - $600Register Now
Designed for forensic toxicologists and pathologists, this 3-day, 15-hour course, covers applied clinical pharmacokinetics in depth and provides the attendees with a sound understanding of most major pharmacokinetic parameters and how to calculate them. Intended as a follow-up to the first day of the Forensic Pharmacology course, this class will take the student deeper into the modeling of biological fluid drug concentration as a function of time.
The interactive experience will be entirely based on problems, questions and case-studies, and will require the use of a calculator and graph paper and will be taught by the renowned Dr. Lionel Raymon.
Cancellations must be notified in writing by emailing firstname.lastname@example.org.
Note: there will be a $150.00 administration fee charged for refunds and/or name changes. All cancellations within 30 days of the scheduled course will receive a 50% refund.
After a brief introduction to pharmacokinetics and pharmacodynamics, the basic concepts of one- and two-compartment models will be laid out and related to distributive properties of drugs. Volume of distribution, and plasma concentration versus time plots will be explored and a logarithm/exponential primer will be reviewed. The student will be able to calculate a volume of distribution, define drug clearance and recognize the differences between first and zero order kinetics. Given a graphic representation or raw data, we will calculate the elimination rate constant and relate it to the drug’s half-life, as well as understand and use the concept of area under the curve (AUC) to calculate a drug clearance and relate it to the dose taken. Comparing single dose against multiple doses of drug administered over time will introduce the concept of steady state and the calculation of estimated trough and peak plasma concentrations will close this first day.
We will explore the relationships between pharmacokinetic parameters. The effect changes in elimination rate constant, in dosing interval, in dose, in clearance or in volume of distribution have on peak and trough concentrations of drugs used chronically will be studied. The students will then explore two-compartment modeling and biexponential equations. Calculation and understanding of a and b (slopes/ distribution and elimination rate constants) will allow the class to appreciate potential problems in the estimation of a drug half-life and define 3 different volumes of distribution (the central compartment volume of distribution, the volume of distribution based on the area under the curve, and the volume of distribution at steady state). Knowing the formulae used in a scientific paper will help interpreting the role clearance has on these values.
Non-linear pharmacokinetics and model-independent pharmacokinetic parameters. The goal is to explain the various processes that can result in non-linear pharmacokinetics and describe the relationships between drug concentration, AUC and dose. The students will use the Michaelis-Menten model to predict plasma drug concentrations. Vmax, Km will be calculated and allow prediction of the dose required to achieve a specific steady-state concentration. Total body clearance, formation clearance and mean residence time of a drug will be addressed.